I've found that wherever I go, I look for good local BBQ and beers. I'm willing to try the sublime and ridiculous especially with my 'Que. I've had watermelon-based sauces, coffee-enhanced rubs, HOT chilies in both rubs and sauces, apricots, peaches, most any Southern fruit... just about any flavor in or on my BBQ. Seek the off-the-beaten-path BBQ joints and look for the long line out the door and you've found a good place.
Local beers are also fun to seek and almost always worth trying. Some bigger cities are lacking with their choices of either brews or 'Ques. Take Memphis. Memphis has possibly the best selection of BBQ of any city but only two local brewers, Ghost River and Bosco's, which is a brewpub. You can find Ghost River all over Beale Street and other areas of the city and in most BBQ joints. Most cities have decent local breweries so Seek and Ye Shall Find.
Remember: Buy Local and Try Local. You'll usually find some hidden gem and have a memorable experience. Be bold, be brave and try something new - you'll be glad you did.